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Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Identifieur interne : 000908 ( Main/Exploration ); précédent : 000907; suivant : 000909

Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Auteurs : Riitta-Liisa Vasunta [Finlande] ; Y. Antero Kes Niemi [Finlande] ; Antti Ylitalo [Finlande] ; Olavi Ukkola [Finlande]

Source :

American journal of hypertension [ 0895-7061 ] ; 2012.

RBID : Pascal:12-0150597

Descripteurs français

Pascal (Inist)
- Athérosclérose, Cardiopathie coronaire, Hypertension artérielle, Pathologie de l'appareil circulatoire, Carotide, Pression artérielle, Pression sanguine, Monitorage.

English descriptors

KwdEn :
- Arterial pressure, Atherosclerosis, Blood pressure, Cardiovascular disease, Carotid, Coronary heart disease, Hypertension, Monitoring.

Abstract

BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.

Affiliations:

Finlande

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Le document en format XML

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<front><div type="abstract" xml:lang="en">BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.</div>
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Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri